MRF Breakthrough Consortium

Mission of the MRFBC

The mission of the MRFBC is to collaborate in order to accelerate the research and development of the most promising therapies in melanoma treatment in order to deliver curative options to patients. 

“We are currenly in a time of unprecedented progress in the development of effective treatments for melanoma. As has been shown for many medical challenges (HIV and TB), it is clear that only through combinations of different therapies will the most significant and durable results be achieved. I believe the MRFBC will bring combinations to our patients in the fastest way.”

- Jedd Wolchok, M.D., Memorial Sloan-Kettering Cancer Center

Learn more about the participating sites or download the MRFBC brochure

Core Strategies

The following initiatives have been identified as fundamental to high impact research. Consortium members are developing an agenda to:

  • Design and execute high-impact clinical trials and combinations of novel single agent therapeutics
  • Develop a collaborative translational research agenda across trials
  • Develop a high quality, virtual specimen repository operating under harmonized SOPs and compliant with regulatory requirements
  • Support animal modeling in appropriate genetic models of melanoma through a collaborative preclinical consortium, thereby accelerating identification of optimal regimens to test in humans in the MRFBC